Polynucleotides (often referred to clinically as PDRN — polydeoxyribonucleotide) are one of the most significant advancements in regenerative aesthetics. Unlike dermal fillers, which physically plump the skin, or anti-wrinkle injections, which paralyse muscles, polynucleotides are "bio-stimulators" that repair tissue at a cellular level.
They consist of highly purified fragments of DNA, typically derived from salmon or trout sperm, which mirror human DNA closely. When injected into the skin, these DNA fragments communicate directly with your fibroblasts (the cells that build the skin's structural matrix). This triggers the production of fresh collagen and elastin, while simultaneously reducing inflammation and promoting angiogenesis (the formation of new micro-blood vessels).
The result is thicker, healthier, and more resilient skin that functions like younger tissue.
Because polynucleotides work by stimulating your body's own regenerative processes, they are highly effective for the delicate under-eye area (tear troughs). Traditional hyaluronic acid fillers in the tear trough can sometimes attract too much water, causing long-term puffiness or a blueish tint (the Tyndall effect). Polynucleotides thicken the skin to hide dark circles without these risks.
Polynucleotides are incredibly versatile and can be used almost anywhere on the face or body where tissue regeneration is needed:
Because polynucleotides are derived from fish DNA, patients with severe fish or seafood allergies must disclose this during consultation. While the DNA is highly purified and stripped of the proteins that typically cause allergic reactions, a patch test may be recommended for highly sensitive individuals. The treatment is not suitable during pregnancy or breastfeeding.
| Region | Per Session |
|---|---|
| London | £350–£500 |
| South East | £300–£440 |
| Midlands | £260–£380 |
| North West | £280–£400 |
| Yorkshire | £260–£380 |
Always verify that your practitioner is registered with the relevant regulatory body (GMC, NMC, GDC, or GPhC). Check the clinic's CQC registration status. Ask about their complication management protocols and whether they carry the appropriate emergency medications.
Visit our full safety guide for the complete list of questions to ask before booking any aesthetic treatment.